A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) C12N 9/10 (2006.01) C12N 15/13 (2006.01) C12N 15/52 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2184688
The invention relates to transgenic non-human mammals characterized in that the genome of said mammals contain at least one heterologous gene encoding for the production of heterologus catalytic entity selected from the group consisting of enzymes and antibodies, and wherein said catalytic entity produces a second heterologous product in the milk of said mammal. Especially useful in the practise of the invention are human glycosyltransferases and transgenic sheep, goats and cows. The heterologous product includes oligosaccharides and glycoconjugates.
L'invention se rapporte à des mammifères transgéniques autres que l'homme qui se caractérisent en ce que leur génome contient au moins un gène hétérologue codant pour la production d'une entité catalytique hétérologue sélectionnée dans le groupe composé d'enzymes et d'anticorps, cette entité catalytique formant un second produit hétérologue dans le lait du mammifere. Les glycosyltransférases humaines ainsi que les moutons, les chèvres et les vaches transgéniques sont particulièrement utiles dans la mise en application de l'invention. Le produit hétérologue comprend des oligosaccharides et des glycoconjugués.
Cummings Richard Dale
Kopchik John Joseph
Moremen Kelley Wilson
Mukerji Pradip
Pierce James Michael
Abbott Laboratories
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Ohio University
University Of Georgia Research Foundation Inc.
University Of Georgia Research Foundation Inc.
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