Transgenic animals with disrupted npy y1 receptor genes

Details Transgenic animals with disrupted npy y1 receptor genes Transgenic animals with disrupted npy y1 receptor genes

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 35/28 (2006.01) A61K 48/00 (2006.01) C07K 14/575 (2006.01) C07K 14/72 (2006.01) C12N 15/85 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2271237

The present invention is directed to transgenic animals which have been engineered by homologous recombination to be deficient in the expression of the neuropeptide Y Y1 receptor. The invention encompasses the DNA constructs and engineered embryonic stem cells used to produce the animals, the transgenic animals themselves, and assays which utilize either the animals or tissues derived from the animals.

L'invention concerne des animaux transgéniques produits par génie génétique au moyen d'une technique de recombinaison homologue, de façon à être déficients en ce qui concerne l'expression du récepteur du neuropeptide Y Y1. L'invention concerne les ADN de recombinaison et les cellules souches embryonnaires mis au point par génie génétique utilisés pour produire lesdits animaux, les animaux transgéniques eux-mêmes, ainsi que des analyses utilisant soit lesdits animaux, soit des tissus qui en proviennent.

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