C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/06 (2006.01) A01K 67/027 (2006.01)
Patent
CA 2385734
The present invention provides methods for creating conditionally-immortal cell lines. These transgenic cell lines can be grown indefinitely in culture while maintaining a relatively undifferentiated stated. Upon appropriate switch signal, the cells cease replicating and differentiate much like adult cells. The switch is facilitated by the inactivation of a transforming gene, such as large T antigen. A convenient methodology for such inactivation is Cre-Lox mediated excision of the gene. Cardiac cells are provided as an example of useful a transgenic cell line. -39-
Bassel-Duby Rhonda S.
Markham David W.
Olson Eric N.
Rybkin Igor I.
Williams R. Sanders
Board Of Regents The University Of Texas System
Goudreau Gage Dubuc
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