Transgenic circulating endothelial cells

Details Transgenic circulating endothelial cells Transgenic circulating endothelial cells

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61L 27/38 (2006.01) A61L 31/00 (2006.01) A61P 7/04 (2006.01) C07K 14/755 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) A61K 35/12 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2351671

A process is provided for expanding the population of endothelial cells obtained from peripheral blood which can be transformed with a vector comprising a DNA sequence encoding a preselected bioactive polypeptide. The resulting transgenic endothelial cells are useful to biocompatibilize implantable medical devices or can be used directly, as for gene therapy.

L'invention concerne un procédé permettant d'accroître la population de cellules endothéliales du sang périphérique, ces cellules pouvant être transformées à l'aide d'un vecteur renfermant une séquence d'ADN codant pour un polypeptide bioactif prédéfini. Les cellules endothéliales transgéniques ainsi obtenues sont notamment utiles pour rendre biocompatibles des dispositifs médicaux implantables, ou peuvent être utilisées directement, par exemple en thérapie génique.

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