Transgenic clawed frog embryos and use thereof as detectors...

Details Transgenic clawed frog embryos and use thereof as detectors... Transgenic clawed frog embryos and use thereof as detectors...

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) A01K 67/027 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2487765

The invention relates to transgenic aquatic animals, particularly the clawed frog and the zebra fish and cells derived therefrom, characterised in comprising at least one expression cassette with a regulatory DNA sequence selected from the response elements to nuclear hormone receptors, particularly TRE, connected in a functional manner downstream of a DNA segment coding for a marker protein such as luciferase or GFP. The invention further relates to methods using the transgenic cells and animals according to the invention for the identification of endocrine disrupters in the environment.

La présente invention concerne des animaux aquatiques transgéniques, notamment le xénope et le poisson zèbre, et les cellules dérivées de ceux-ci, caractérisé en ce qu'ils comprennent au moins une cassette d'expression comprenant une séquence d'ADN régulatrice sélectionnée parmi les éléments de réponse aux récepteurs nucléaires d'hormones, notamment le TRE, liée de manière opérationnelle en amont d'un segment d'ADN codant pour une protéine rapporteuse, tels la luciférase ou l'eGFP. L'invention concerne également des procédés mettant en oeuvre les cellules et animaux transgéniques de l'invention et destinés à identifier la présence de perturbateurs endocriniens dans l'environnement.

Affiliated with

Also associated with

Rating

Transgenic clawed frog embryos and use thereof as detectors... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Transgenic clawed frog embryos and use thereof as detectors..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transgenic clawed frog embryos and use thereof as detectors... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1375011