Transgenic, cross-linked hemoglobin

Details Transgenic, cross-linked hemoglobin Transgenic, cross-linked hemoglobin

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A01K 67/027 (2006.01) A61K 35/14 (2006.01) A61K 38/42 (2006.01) C07K 14/805 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2098818

2098818 9211283 PCTABS00014 Transgenic, recombinantly cross-linked polymeric human hemoglobins suitable as cell-free blood substitutes have been produced. A plurality of DNA constructs have been designed for efficient expression of modified human hemoglobins in the erythrocytes of the non-human transgenic animals. Substantially pure, non-immunogenic, artificial human hemoglobins are then easily obtained from the erythroid of the transgenic animals.

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