Transgenic drosophilia melanogaster expressing beta amyloid

Details Transgenic drosophilia melanogaster expressing beta amyloid Transgenic drosophilia melanogaster expressing beta amyloid

A - Human Necessities

01

K

A01K 67/033 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2423613

Transgenic files displaying altered phenotypes due to expression of the Abeta and C99 portions of the human APP gene are disclosed. Use of these files in a method to identify Drosophila genes and the human homologs of these Drosophila genes, that are potentially involved in Alzheimer's Disease, is also disclosed. The use of said human homologs as drug targets for the development of therapeutics to treat Alzheimer's Disease and other conditions associated with defects in the APP pathway, as well as pharmaceutical compositions comprising substances directed to these genes, are also disclosed.

L'invention concerne des mouches transgéniques présentant des phénotypes modifiés en raison de l'expression de la protéine bêta-amyloïde et des parties C99 du gène humain <i>APP</i>. L'utilisation de ces mouches dans un procédé d'identification de gènes de Drosophila et les homologues humains de ces gènes, qui sont potentiellement impliqués dans la maladie d'Alzheimer. L'utilisation de ces homologues humains en tant que cibles médicamenteuses destinées au développement de thérapies de traitement de la maladie d'Alzheimer et d'autres états associés aux défauts dans la voie de protéine précurseur amyloïde, ainsi qu'en tant que compositions pharmaceutiques comprenant des substances destinées à ces gènes.

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