Transgenic fibrinogen

A - Human Necessities – 01 – K

Patent

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Details

A01K 67/027 (2006.01) C07K 14/75 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2183546

Transgenic non-human animals, capable of expressing a heterologous gene for human or other recombinant fibrinogen protein or subunit chain polypeptides thereof or modified fibrinogens in mammary glands of the animals and secreting the expressed product into a body fluid, are provided, as are methods of producing recombinant fibrinogens, subunit chains polypeptides thereof and modified fibrinogens, and fibrinogens fusion proteins in such animals.

L'invention concerne des animaux transgéniques capables d'exprimer un gène hétérologue pour une protéine de fibrinogène recombinée humaine ou autre, ou des polypeptides à chaînes sous-unitaires ou encore des fibrinogènes modifiés dans les glandes mammaires de ces animaux, et de secréter le produit exprimé dans un liquide biologique. Elle concerne aussi des techniques de production de fibrinogènes recombinés, de polypeptides à chaînes sous-unitaires de ces fibrinogènes et de fibrinogènes modifiés, et de protéines de fusion des fibrinogènes rencontrés chez ces animaux.

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