Transgenic fish and vectors therefor

Details Transgenic fish and vectors therefor Transgenic fish and vectors therefor

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A01K 67/027 (2006.01) C07K 14/46 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12N 15/89 (2006.01)

Patent

CA 2126138

Sockeye salmon growth hormone genes Types 1 and 2, and sockeye histone and metallothionein gene promoters have been isolated and sequenced. Terminator sequences for the growth hormone gene have been found. Vectors containing these promoter and terminator sequences (and intermediate sequences) have been prepared and used to transform fish egg cells. Transformed fish egg cells have been grown into transgenic fish. In the case of inserted full-length growth hormone gene, both accelerated growth and early smoltification were observed. An aspect found beneficial is to combine homologous fish metallothionein or histone gene promoter with fish gene, preferably growth hormone gene, terminator in the same vector, for preparing transgenic fish.

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