Transgenic flies expressing mutant a.beta.42

Details Transgenic flies expressing mutant a.beta.42 Transgenic flies expressing mutant a.beta.42

A - Human Necessities

01

K

A01K 67/033 (2006.01) G01N 33/00 (2006.01)

Patent

CA 2543058

The present invention discloses a transgenic fly that expresses the Iowa mutant version of the human A.beta.42 peptide of human amyloid-.beta. precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human A.beta.Iowa peptide of human amyloid-.beta. precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.

L'invention concerne une mouche transgénique qui exprime la version mutante lowa du peptide humain A.beta.42 de la protéine précurseur d'amyloïde .beta. humain (APP), et une mouche double transgénique qui exprime à la fois, la protéine Tau et le peptide A.beta.42¿lowa? humain de la protéine précurseur d'amyloïde .beta. humain (APP). Les mouches transgéniques selon l'invention fournissent des modèles de troubles neurodégénératifs, tels que la maladie d'Alzheimer. L'invention concerne en outre des procédés d'identification de modificateurs génétiques, ainsi que des procédés de criblage permettant d'identifier des composés thérapeutiques, en vue de traiter des troubles neurodégénératifs au moyen des mouches transgéniques.

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