Transgenic knockouts of bace-1

Details Transgenic knockouts of bace-1 Transgenic knockouts of bace-1

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C12N 5/0735 (2010.01) A01K 67/02 (2006.01) A01K 67/027 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2438832

The invention provides transgenic animals that are heterozygous or homozygous for a nonfunctional allele of BACE-1. These animals show normal development indicating that BACE-1 is not necessary for development and hence is an appropriate therapeutic target. The transgenic animals are useful in various screening assays including identifying inhibitors of other enzymes involved in processing of APP to A.szlig. and determining a toxicity profile of inhibitors of BACE-1.

L'invention concerne des animaux transgéniques qui sont hétérozygotes ou homozygotes pour un allèle non-fonctionnel de BACE-1. Ces animaux présentent un développement normal indiquant que BACE-1 n'est pas nécessaire pour le développement et ainsi qu'elle est une cible thérapeutique appropriée. Ces animaux transgéniques sont utiles dans plusieurs essais de criblage, y compris l'identification d'inhibiteurs d'autres enzymes impliquées dans la transformation du précurseur APP en A.beta. et la détermination du profil de toxicité des inhibiteurs de BACE-1.

Affiliated with

Also associated with

Rating

Transgenic knockouts of bace-1 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Transgenic knockouts of bace-1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transgenic knockouts of bace-1 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1480455