Transgenic mammal carrying ganp gene transferred thereinto...

A - Human Necessities – 01 – K

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A01K 67/027 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2504867

It is intended to provide a high-affinity antibody efficacious as a diagnostic and a remedy for various diseases, a transgenic mammal for producing the antibody and a drug with the use of the high-affinity antibody or high- affinity antibody-producing cells. Thus, a transgenic mammal carrying a GANP gene transferred thereinto, its offspring or part thereof and a process for producing a high-affinity antibody using the same.

L'invention vise à mettre au point un anticorps à haute affinité, s'avérant efficace comme agent diagnostique et comme médicament pour différentes pathologies. L'invention concerne un mammifère transgénique utilisé pour produire ledit anticorps et un médicament, à l'aide dudit anticorps à haute affinité ou de cellules produisant l'anticorps à haute affinité. L'invention concerne par conséquent un mammifère transgénique portant un gène de la GANP transféré dedans, sa progéniture ou une partie de ladite progéniture, ainsi qu'un procédé permettant de produire un anticorps à haute affinité, à l'aide dudit mammifère transgénique.

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