C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) A01K 67/027 (2006.01) C07K 16/00 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/13 (2006.01) C12N 15/85 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2722378
The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (V H and V .KAPPA. regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B- cell development to the animals, such that the animals possess abundant mature B--cells secreting extremely high affinity antibodies.
Green Larry
Jakobovits Aya
Klapholz Sue
Kucherlapati Raju
Mendez Michael
Amgen Fremont Inc.
Smart & Biggar
LandOfFree
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