Transgenic mammals lacking expression of particular cd45...

Details Transgenic mammals lacking expression of particular cd45... Transgenic mammals lacking expression of particular cd45...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) G01N 33/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2161015

A mammal lacking expression of particular CD45 isoform in certain cells of the immune system is provided. The mammal may optionally contain a transgene encoding the CD45RO isoform. Also provided are methods of using these mammals.

Obtention de mammifères chez qui l'expression d'isoformes CD45 particuliers par certaines cellules du système immunitaire est absente. Ces mammifères peuvent facultativement être porteurs d'un transgène codant pour l'isoforme CD45RO. Sont également décrites des méthodes d'utilisation desdits mammifères.

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