Transgenic mice

A - Human Necessities – 01 – K

Patent

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Details

A01K 67/027 (2006.01) C07K 14/47 (2006.01) C12N 9/10 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2696934

The present invention provides a transgenic non-human animal, in particular a transgenic mouse encoding A.beta. peptide proteins, which have been implicated in A.beta. peptide-related diseases. The present invention additionally provides cells and cell lines comprising transgenes encoding for A.beta. peptide. The present invention further provides methods and compositions for evaluating agents that affect A.beta. peptide, for use in compositions for the treatment of A.beta. peptide-related diseases.

La présente invention concerne un animal non humain transgénique, notamment une souris transgénique qui code pour des protéines peptides Aß, qui ont été impliquées dans des maladies associées au peptide Aß. La présente invention concerne également des cellules et des lignées cellulaires qui comprennent des transgènes qui codent pour le peptide Aß. La présente invention concerne également des procédés et des compositions pour l'évaluation d'agents qui affectent le peptide Aß, pour une utilisation dans des compositions pour le traitement de maladies associées au peptide Aß.

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