Transgenic mice carrying hp-2 gene and uses as models for...

Details Transgenic mice carrying hp-2 gene and uses as models for... Transgenic mice carrying hp-2 gene and uses as models for...

C - Chemistry, Metallurgy

12

P

C12P 21/00 (2006.01)

Patent

CA 2613348

This invention provides transgenic mice carrying the humanizedHp-2 allele for haptoglobin. Specifically, provided herein is methods of the use of these transgenic mice in the diagnosis and rational drug design of compounds to be used in the treatment of vascular complications in diabetic subjects carrying the Hp-2 gene.

L'invention concerne une souris transgénique qui porte l'allèle humanisé Hp-2 de l'haptoglobine. Plus spécifiquement, l'invention concerne des procédés d'utilisation de cette souris transgénique dans le diagnostic et l'élaboration rationnelle de médicaments à partir de composés servant à traiter les complications vasculaires chez les sujets diabétiques portant le gène Hp-2.

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