A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) A61K 49/00 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12N 15/90 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2410659
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in the MCAR orphan nuclear hormone receptor gene such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions, in particular diseases of the spleen, thymus or lymph nodes.
L'invention concerne des animaux transgéniques ainsi que des compositions et des procédés concernant la caractérisation de la fonction génique. Plus spécifiquement, la présente invention concerne des souris transgéniques contenant des mutations dans un gène de récepteur hormonal nucléaire. De telles souris transgéniques sont utiles en tant que modèles pour des maladies et pour identifier les agents qui modulent l'expression génique et la fonction génique, et également en tant que traitements potentiels pour différents états pathologiques.
Brennan Thomas J.
Guenther Catherine
Barrigar Intellectual Property Law
Deltagen Inc.
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