Transgenic mice expressing human cd20

Details Transgenic mice expressing human cd20 Transgenic mice expressing human cd20

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) A01K 67/027 (2006.01) A01K 67/033 (2006.01) C12N 15/00 (2006.01) C12P 21/00 (2006.01) G01N 33/00 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2507882

The present invention generally relates to non-human transgenic animals expressing human cellular markers, including CD20 and methods for using the animals to identify agents that are effective to deplete cells bearing human CD20. The transgenic animals are also useful to test safety and efficacy of anti-CD20 therapies.

La présente invention concerne généralement des animaux transgéniques non humains exprimant des marqueurs cellulaires humains, dont CD20. Elle concerne également des méthodes d'utilisation desdits animaux pour identifier des agents pouvant appauvrir efficacement des cellules porteuses du CD20 humain. Les animaux transgéniques de l'invention peuvent également être utilisés pour tester la sécurité et l'efficacité de traitement anti-CD20.

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