A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) A61K 49/00 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2534090
The present invention relates to transgenic mice and isolated transgenic mouse cells, the mice and mouse cells comprising a disrupted H2 class I gene, a disrupted H2 class II gene, a functional HLA class I transgene, and a functional HLA class II transgene. In embodiments, the transgenic mouse or mouse cells are deficient for both H2 class I and class II molecules, wherein the transgenic mouse comprises a functional HLA class I transgene and a functional HLA class II transgene. In embodiments, the transgenic mouse or mouse cell has the genotype HLA-A2+HLA-DR1+.szlig.2m~IA.szlig.~. The invention also relates to methods of using a transgenic mouse of the invention.
L'invention concerne des souris transgéniques et des cellules isolées de souris transgéniques, les souris et les cellules de souris qui comprennent un gène éclaté de classe I H2, un gène éclaté de classe II H2, un transgène fonctionnel de classe I HLA et un transgène fonctionnel de classe II HLA. Dans les modes de réalisation, les souris transgéniques ou les cellules de souris manquent aussi bien des molécules de la classe I H2 que de la classe II, la souris transgénique comprenant un transgène fonctionnel de classe I HLA et un transgène fonctionnel de classe II HLA. Dans les modes de réalisation, la souris transgénique ou la cellule de souris a le génotype HLA-A2?+¿HLA-DR1?+¿.szlig.2m·IAp·. L'invention concerne également des méthodes d'utilisation de la souris transgénique décrite.
Auriault Claude
Lemonnier Francois
Lone Yu-Chun
Pajot Anthony
Pancre Veronique
Institut Pasteur
Robic
LandOfFree
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