A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01)
Patent
CA 2560551
The present invention relates to a transgenic non-human animal expressing at least one transgene comprising a DNA sequence encoding a heterologous Amyloid Precursor Protein (APP) comprising at least the Arctic mutation (E693G) and a further AD (Alzheimer's disease) pathogenic mutation or a further transgene affecting AD pathogenesis, which results in increased amounts of intracellular soluble A aggregates, including A peptides. The present invention also relates to method of producing said transgenic animal, and to methods of screening for therapeutic or diagnostic agents useful in treatment or diagnosis of Alzheimer's disease.
La présente invention concerne un animal non humain transgénique exprimant au moins un transgène qui renferme une séquence d'ADN codant une protéine précurseur amyloïde hétérologue (APP) contenant au moins la mutation <= arctique >= (E693G) et une autre mutation pathogène de la maladie d'Alzheimer ou encore un autre transgène affectant la pathogénèse de la maladie d'Alzheimer, ce qui débouche sur des quantités accrues d'agrégats A.beta. solubles intracellulaires, notamment, des peptides A.beta.. Cette invention a également pour objet une méthode d'élaboration dudit animal transgénique et des méthodes de criblage d'agents thérapeutiques ou diagnostiques utilisés dans le traitement ou le diagnostic de la maladie d'Alzheimer.
Gellerfors Paer
Lannfelt Lars
Nilsson Lars
Bioarctic Neuroscience Ab
Cassan Maclean
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