C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01) C07K 14/435 (2006.01) C07K 14/475 (2006.01) C12N 5/06 (2006.01) C12N 5/10 (2006.01)
Patent
CA 2331882
A transgenic mammal, specifically a mouse, containing in its genome a humanized mutant of green fluorescent protein operably linked to the glial fibrillary acidic protein promoter is provided. The mouse can be used to assay the effects of systemic or topical administration of neurotoxins and also to assay the effects of physical damage to neural tissue.
On décrit un mammifère transgénique, plus spécifiquement une souris qui contient dans son génome un mutant humanisé de protéine verte fluorescente lié de manière efficace au promoteur de protéine acide fibrillaire de névroglie. La souris peut être utilisée pour évaluer les effets de l'administration systémique ou topique de neurotoxines et pour évaluer les effets des dommages physiques sur les tissus nerveux.
Messing Albee
Murphy Christopher J.
Zhuo Lang
Torys Llp
Wisconsin Alumni Research Foundation
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