Transgenic non-human animal and methods for stem cell...

C - Chemistry – Metallurgy – 12 – N

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C12N 5/10 (2006.01) A01K 67/027 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) C07K 14/52 (2006.01) C12N 15/19 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2720567

Transgenic immunodeficient non-human animals according to embodiments of the present invention are described which include in their genome a nucleic acid encoding xenogeneic Stem Cell Factor operably linked to a promoter. Administration of xenogeneic hematopoetic stem cells to the inventive transgenic animals results in engraftment of the xenogeneic hematopoetic stem cells and xenogeneic leukocytes are produced in the animals, without conditioning such as without conditioning by irradiation and without conditioning by a radiomimetic agent.

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