Transgenic non-human animals depleted in a mature...

Details Transgenic non-human animals depleted in a mature... Transgenic non-human animals depleted in a mature...

C - Chemistry, Metallurgy

12

N

195/1.22, 195/1.

C12N 15/00 (2006.01) C07K 14/725 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2004477

ABSTRACT OF THE DISCLOSURE Transgenic non-human animals having a phenotype characterized by the substantial depletion of a mature lymphocytic cell type otherwise naturally occurring in the species from which the transgenic animal is derived. The phenotype is conferred in the transgenic animal by a transgene contained in at least the precursor stem cell of the lymphocytic cell type which is depleted. The transgene comprises a DNA sequence encoding a lymphatic polypeptide variant which inhibits maturation of the lymphocytic cell type.

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