C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01) C07K 14/745 (2006.01) C07K 14/755 (2006.01) C12N 9/64 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2710567
The present invention relates, in general, to development of non-human transgenic animals expressing a human blood clotting factor, such as Factor VIII, Factor VII, Factor IX and von Willebrand factor. The invention further provides methods of detecting immunogenic events against human blood clotting factor using the transgenic animals described.
L'invention concerne de manière générale le développement d'animaux transgéniques non humains exprimant un facteur de coagulation de sang humain, comme le facteur VIII, le facteur VII, le facteur IX, et le facteur de von Willebrand. L'invention concerne en outre des procédés de détection d'événements immunogéniques à l'encontre du facteur de coagulation de sang humain utilisant les animaux transgéniques décrits.
Antoine Gerhard
Ehrlich Hartmut
Reipert Birgit
Sasgary Maria
Schuster Maria
Baxter Healthcare S.a.
Baxter International Inc.
Sim & Mcburney
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