C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) A01K 67/00 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2444451
The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes or portions of genes have been replaced by homologues from another animal to make the physiology of the animals so modified more like that of the other animal with respect to drug pharmacokinetics and metabolism. The invention also extends to the use of the genetically modified non-human animals of the invention for pharmacological and/or toxicological studies.
La présente invention concerne la production, l'élevage et l'utilisation d'animaux transgéniques tels que des souris dans lesquels des gènes spécifiques ou des parties de gènes spécifiques ont été remplacés par des homologues provenant d'un autre animal de façon à modifier la physiologie de ces animaux et faire en sorte que cette dernière soit plus semblable à celle de l'autre animal pour ce qui concerne la pharmacocinétique et le métabolisme de médicament. Cette invention concerne aussi l'utilisation des animaux génétiquement modifiés à des fins d'études pharmacologiques et/ou toxicologiques.
Fetherstonhaugh & Co.
Gene Stream Pty Ltd
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