Transgenic non-human mammal

Details Transgenic non-human mammal Transgenic non-human mammal

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/00 (2006.01) A61P 17/06 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C12N 5/08 (2006.01) C12N 9/10 (2006.01) C12N 15/85 (2006.01) C12P 19/34 (2006.01) C12P 21/00 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2407295

The invention features transgenic non-human mammals and transgenic cells expressing a radical fringe transgene comprising a radical fringe coding sequence, wherein expression of said coding sequence in said mammal is driven by an operably linked regulatory sequence that directs inducible and keratinocyte- specific expression, and wherein said mammal exhibits accelerated wound healing and/or increased keratinocyte proliferation following the induction of transgene expression. The invention also features polynucleotide (SEQ ID NO:1) and amino acid (SEQ ID NO:2) sequences for human radical fringe, methods of treating psoriasis and promoting wound healing by administering a modulator of radical fringe polypeptide activity, and methods of identifying modulators of radical fringe activity.

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