Transgenic non-human mammals with an oncogenic mutant of raf...

Details Transgenic non-human mammals with an oncogenic mutant of raf... Transgenic non-human mammals with an oncogenic mutant of raf...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01) C07K 14/82 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/85 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2311599

The invention relates to a transgenic non-human mammal whose cells express a constitutively active oncogenic mutant of the kinese-domain of the Raf-1-gene or a protein coded by a corresponding normal allele or derivative of the A, B or c-Raf-1 gene.

L'invention concerne un mammifère transgénique non humain, dont les cellules expriment une protéine codée par un mutant oncogène constitutivement actif du domaine kinase du gène Raf-1 ou bien une protéine codée par un allèle ou un dérivé normal correspondant du gène A, B ou c-Raf-1.

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