Transgenic pig as a model of alzheimer's disease

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/00 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2717239

The present invention relates to a modified pig as a model for studying Alzheimer's disease. The modified pig model displays one or more phenotypes associated with Alzheimer's disease. Disclosed is also a modified pig comprising a modified human and/or porcine APP gene, and/or PS1 gene, and/or a transcriptional and/or translational product or part thereof. The invention further relates to methods for producing the modified pig; and methods for evaluating the effect of a therapeutical treatment of Alzheimer's disease; methods for screening the efficacy of a pharmaceutical composition; and a method for treatment of a human being suffering from Alzheimer's disease are disclosed.

La présente invention concerne un cochon modifié utilisé comme modèle pour étudier la maladie d'Alzheimer. Le cochon modifié utilisé comme modèle présente un ou plusieurs phénotypes associés à la maladie d'Alzheimer. L'invention concerne également un cochon modifié comprenant un gène APP et/ou un gène PS1 humain et/ou porcin modifié et/ou un produit transcriptionnel et/ou translationnel ou une partie de ceux-ci. L'invention concerne en outre des procédés de production du cochon modifié ; et des procédés d'évaluation de l'effet d'un traitement thérapeutique de la maladie d'Alzheimer ; des procédés de détection de l'efficacité d'une composition pharmaceutique ; et un procédé de traitement d'un être humain souffrant de la maladie d'Alzheimer.

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