C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A01H 4/00 (2006.01) A01H 5/00 (2006.01) A01H 5/10 (2006.01) A23D 9/007 (2006.01) A61K 31/355 (2006.01) A61K 31/575 (2006.01) A61P 3/06 (2006.01) C07J 9/00 (2006.01) C12N 5/04 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 9/04 (2006.01) C12N 9/10 (2006.01) C12N 15/53 (2006.01) C12N 15/82 (2006.01) C12P 15/00 (2006.01) C12P 17/06 (2006.01) C12P 21/02 (2006.01) C12P 33/00 (2006.01)
Patent
CA 2433532
Disclosed are constructs comprising sequences encoding 3-hydroxy- 3methylglutaryl-Coenzyme A reductase and at least one other sterol synthesis pathway enzyme. Also disclosed are methods for using such constructs to alter sterol production and content in cells, plants, seeds and storage organs of plants. Also provided are oils and compositions containing altered sterol levels produced by use of the disclosed constructs. Novel nucleotide sequences useful in the alteration of sterol production are also provided. Also provided are cells, plants, seeds and storage organs of plants comprising sequences encoding 3-hydroxy-3methylglutaryl-Coenzyme A reductase, at least one other sterol synthesis pathway enzyme and at least one tocopherol synthesis enzyme.
La présente invention concerne des constructions comportant des séquences codant pour la 3-hydroxy-3-méthylglutaryle-coenzyme A réductase (HMG CoA-réductase) et au moins une autre enzyme de la voie de synthèse des stérols. L'invention concerne également des procédés d'utilisation de telles constructions en vue de modifier la production et le contenu de stérols dans des cellules, des plantes, des graines et des organes de stockage des plantes. L'invention concerne en outre des huiles et des compositions contenant des niveaux de stérol modifié produites au moyen desdites constructions. L'invention concerne aussi de nouvelles séquences nucléotidiques utilisables dans la modification de la production de stérols. Enfin, l'invention concerne des cellules, des plantes, des graines et de organes de stockage de plantes comportant des séquences codant pour la A 3-hydroxy-3-méthylglutaryle-coenzyme A réductase (HMG CoA-réductase), au moins une autre enzyme de la voie de synthèse des stérols et au moins une enzyme de synthèse de tocophérol. Fig. 1 : 1 SQUALENE 2 SQUALENE EPOXIDASE 3 STEROL METHYLE TRANSFERASE 4 24-METHYLENE CYCLOARTENOL 5 STEROL C4-DEMETHYLASE 6 CYCLOARTENOL 7 OBTUSIFOLIOL 8 OBTUSIFOLIOL C14.alpha.-DEMETHYLASE 9 STIGMASTA-7-ENOL 10 STEROL C5-DESATURASE 11 CAMPESTEROL 12 STEROL METHYLE TRANSFERASE II 13 SITOSTEROL 14 STIGMASTEROL 15 SITOSTANOL
Karunanandaa Balasulojini
Kishore Ganesh M.
Ledeaux John
Post-Beittenmiller Martha
Thorne Gregory M.
Mcfadden Fincham
Monsanto Technology Llc
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