C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/82 (2006.01) A01H 5/00 (2006.01) A61K 31/56 (2006.01) A61P 43/00 (2006.01) C07J 9/00 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 15/53 (2006.01) C12N 15/54 (2006.01) C12P 33/00 (2006.01)
Patent
CA 2372120
Provided are recombinant constructs comprising DNA sequences encoding enzymes effective in altering the biosynthesis and accumulation of sterol compounds and tocopherols in transgenic plants. Also provided are methods of using such constructs to produce transgenic plants, seeds of which contain elevated levels of sitostanol and/or sitostanol esters, and .alpha.-tocopherol, as well as reduced levels of campesterol and campestanol and their corresponding esters. These seeds also contain the novel sterol brassicastanol. Oil obtained from seeds of such transgenic plants is also provided. This oil can be used to prepare food and pharmaceutical compositions effective in lowering the level of low density lipoprotein cholesterol in blood serum. In addition, novel DNA sequences encoding plant steroid 5.alpha.-reductases are also disclosed.
L'invention concerne des structures de recombinaison renfermant des séquences d'ADN qui codent des enzymes efficaces dans la modification de la biosynthèse et de l'accumulation des composés au stérol et des tocophérols dans les plantes transgéniques. L'invention concerne également des procédés relatifs à l'utilisation de ces structures pour la production de plantes transgéniques, dont les graines contiennent des niveaux élevés de sitostanol et/ou d'esters de sitostanol, et d'alpha-tocophérol, ainsi que des niveaux réduits de campestérol et de campestanol et leurs esters correspondants. Les graines en question contiennent également le nouveau stérol brassicastanol. L'invention concerne également l'huile provenant desdites graines. On peut utiliser l'huile en question pour élaborer des produits alimentaires et des compositions pharmaceutiques efficaces dans la réduction du taux de cholestérol à lipoprotéines de basse densité dans le sérum. L'invention concerne enfin de nouvelles séquences d'ADN codant les réductases 5.alpha. stéroïdes de plantes.
Bhat Ganesh B.
Boddupalli Sekhar S.
Corbin David R.
Grebenok Robert J.
Karunanandaa Balasulojini
Mcfadden Fincham
Monsanto Company
Monsanto Technology Llc
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