C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) A61K 49/00 (2006.01) C07K 14/775 (2006.01) C12N 9/00 (2006.01) C12N 11/10 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01) G01N 31/00 (2006.01)
Patent
CA 2316808
A transgenic rabbit which has in its genomic DNA sequences that encode apolipoprotein (a) and apolipoprotein B polypeptides which are capable of combining to produce lipoprotein (a), a process for creating such a rabbit, and the use of the rabbit to identify compounds which are effective in the treatment of human diseases which are associated with, induced and/or exacerbated by Lp(a) expression.
L'invention concerne un lapin transgénique comprenant des séquences d'ADN génomique codant des polypeptides d'apolipoprotéine (a) et d'apolipoprotéine B capables de se combiner pour produire une lipoprotéine (a), un procédé de création d'un tel lapin et l'utilisation du lapin pour identifier des composés qui sont efficaces dans le traitement de maladies humaines associées à, induites et/ou exacerbées par l'expression Lp(a).
Denefle Patrice
Duverger Nicolas
Emmanuel Florence
Houdebine Louis-Marie
Hughes Steven D.
Aventis Pharmaceuticals Inc.
Aventis Pharmaceuticals Products Inc.
Deeth Williams Wall Llp
Institut National de La Recherche Agronomique
The Regents Of The University Of California
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