Transgenic rabbits expressing cd4 and chemokine receptor

Details Transgenic rabbits expressing cd4 and chemokine receptor Transgenic rabbits expressing cd4 and chemokine receptor

A - Human Necessities

01

K

A01K 67/027 (2006.01) C07K 14/715 (2006.01) C07K 14/73 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2295059

The invention provides transgenic rabbits and transgenic rabbit cells expessing CD4 and a human chemokine receptor such as CXR4 or CCR5. The invention also provides methods of generating the transgenic rabbit. The double transgene is either generated by introducing the two transgenic entities into a fertilized pronucleus or by breeding two transgenic rabbits each ahving one of the transgenic entities. The rabbit may be infected with HIV.

Cette invention se rapporte à des lapins transgéniques et à des cellules de lapins transgéniques exprimant la molécule CD4 et un récepteur de chimiokine humaine tel que CXR4 ou CCR5. Cette invention se rapporte également à des procédés de création de tels lapins transgéniques. On génère le double transgène soit en introduisant les deux entités transgéniques dans un pronucleus fécondé, soit en élevant deux lapins transgéniques possédant chacun une des entités transgéniques. Ce lapin peut être contaminé par le VIH.

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