Transgenic ro s a26-luc i f eras e mice for bioluminescent...

Details Transgenic ro s a26-luc i f eras e mice for bioluminescent... Transgenic ro s a26-luc i f eras e mice for bioluminescent...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12Q 1/00 (2006.01) C12Q 1/66 (2006.01)

Patent

CA 2625864

The invention relates to non-human transgenic animals expressing bioluminescent markers . The invention provides a transgenic mouse whose genome comprises a nucleotide sequence encoding lucif erase, operably linked to murine control sequences whereby the lucif erase is expressed in all cells. Administration of a luciferin substrate to the mouse results in bioluminescence . The control sequence is the Rosa 26 promoter . This mouse is useful to monitor in situ cell growth, differentiation or proliferation

L'invention concerne des animaux transgéniques surveillés par imagerie bioluminescence

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