Transgenic ungulates capable of human antibody production

Details Transgenic ungulates capable of human antibody production Transgenic ungulates capable of human antibody production

A - Human Necessities

01

K

A01K 67/027 (2006.01) C12N 5/10 (2006.01) C12N 15/02 (2006.01) C12N 15/09 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2484655

The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e.g., non-bovine antibodies), preferably human antibodies.

L'invention concerne de nouvelles méthodes de production de grandes quantités d'anticorps xénogéniques, tels que des anticorps humains. Ces grandes quantités d'anticorps sont, de préférence, obtenues par l'inactivation de l'expression de la chaîne lourde des IgM et, éventuellement, par l'inactivation de l'expression de la chaîne légère des Ig et par l'introduction ultérieure d'un chromosome artificiel entraînant l'expression d'anticorps xénogéniques (p. ex. d'anticorps non bovins), de préférence d'anticorps humains.

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