Transgenic ungulates expressing ctla4-ig and uses thereof

Details Transgenic ungulates expressing ctla4-ig and uses thereof Transgenic ungulates expressing ctla4-ig and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C07K 14/725 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2617930

The present invention provides ungulates, including pigs, expressing CTLA4-Ig, as well as tissue, organs, cells and cell lines derived from such animals. Such animals, tissues, organs and cells can be used in research and medical therapy, including xenotransplanation. In addition, methods are provided to prepare organs, tissues and cells expressing the CTLA4-Ig for use in xenotransplantation, and nucleic acid constructs and vectors useful therein.

L'invention porte sur des ongulés dont des porcs exprimant la CTLA4-Ig, ainsi que sur des tissus, des organes, des cellules et des lignées de cellules provenant de tels animaux. Lesdits animaux et leurs tissus, organes, cellules et lignées de cellules peuvent servir à des recherches et à des traitements médicaux dont les xénotransplantation, les chimères d'acides nucléiques et des vecteurs utiles s'y trouvant.

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