Transgenic ungulates having reduced prion protein activity...

Details Transgenic ungulates having reduced prion protein activity... Transgenic ungulates having reduced prion protein activity...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/13 (2006.01) C12N 15/85 (2006.01) C12N 15/90 (2006.01) C12P 21/00 (2006.01) C12P 21/08 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2502490

The invention provides cloned transgenic ungulates (e.g., bovines) in which prion protein activity is reduced by one or more genetically engineered mutations. Desirably, these transgenic bovines are also genetically modified to express xenogenous (e.g., human) antibodies. Because of their resistance to prion-related diseases such as bovine spongiform encephalopy (also known as mad cow disease), these bovines are a safer source of human antibodies for pharmaceutical uses and safer source of agricultural products.

L'invention concerne des ongulés transgéniques, clonés (par exemple des bovins), chez lesquels l'activité de la protéine prion est réduite par une ou plusieurs mutations génétiquement modifiées. De préférence, lesdits bovins transgéniques sont également génétiquement modifiés, de manière à exprimer des anticorps xénogènes (par exemple des anticorps humains). Du fait de leur résistance aux maladies associées au prion telles que l'encéphalopathie spongiforme bovine (connue également sous le nom de maladie de la vache folle), les bovins sont une source plus sûre d'anticorps humains pour des utilisations pharmaceutiques et une source plus sûre de produits agricoles.

Affiliated with

Also associated with

Rating

Transgenic ungulates having reduced prion protein activity... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Transgenic ungulates having reduced prion protein activity..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transgenic ungulates having reduced prion protein activity... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1907115