Transgenic zebrafish models for neurodegenerative diseases

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) C12N 15/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/00 (2006.01) C12Q 1/04 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2443364

The present invention relates to zebrafish models for neurodegenerative disorders that allow screening of compounds for their ability to protect and/or regenerate neurons in vivo in a whole vertebrate organism. The present invention also provides methods of identifying gene targets for neuroprotective compounds, compounds that regenerate neurons and compounds that promote neurogenesis.

L'invention concerne des modèles de poisson zébré destinés à des troubles neurodégénératifs permettant le criblage de composés pour leur capacité à protéger et/ou à régénérer des neurones in vivo dans un organisme vertébré entier. Cette invention concerne aussi des procédés d'identification de cibles géniques destinées à des composés neuroprotecteurs, des composés régénérant les neurones et des composés promouvant la neurogenèse.

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