Transgenic zebrafish models for thrombosis

Details Transgenic zebrafish models for thrombosis Transgenic zebrafish models for thrombosis

A - Human Necessities

01

K

A01K 67/00 (2006.01) A01K 67/033 (2006.01) A61K 49/00 (2006.01) C07K 14/435 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/00 (2006.01)

Patent

CA 2477624

The present invention relates to zebrafish models of thrombosis that allow screening of compounds for anti-thrombotic or thrombotic properties in vivo in a whole vertebrate organism. The present invention also relates to the identification and validation of platelet genes as targets for anti-thrombotic or thrombotic compounds.

L'invention concerne des modèles de poissons zèbres pour des composés empêchant la thrombose, lesdits modèles permettant le criblage de composés présentant des propriétés antithrombotiques ou thrombotiques in vivo dans l'ensemble de l'organisme d'un vertébré. L'invention concerne l'identification et la validation de gènes de plaquettes en tant que cibles pour des composés antithrombotiques et thrombotiques.

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