Transgenically produced antithrombin iii and mutants thereof

Details Transgenically produced antithrombin iii and mutants thereof Transgenically produced antithrombin iii and mutants thereof

C - Chemistry, Metallurgy

07

K

C07K 14/81 (2006.01) A01K 67/00 (2006.01) A61K 38/16 (2006.01) A61K 38/55 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2368608

The invention features transgenically produced mutants of Antithrombin III, e.g., transgenically produced mutants of ATIII having enhanced antiangiogenic activity. The invention also features methods of making mutants of ATIII, and transgenic organisms which express a mutated ATIII.

L'invention concerne des mutants de l'antithrombine III produits de manière transgénique, p. ex. des mutants d'ATIII produits de manière transgénique qui possèdent une activité anti-angiogénique accrue. L'invention concerne également des procédés de fabrication de mutants d'ATIII et des organismes transgéniques qui expriment une ATIII mutante.

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