C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/00 (2006.01) A01K 67/00 (2006.01) A61K 38/24 (2006.01) C07H 21/04 (2006.01) C07K 14/49 (2006.01) C12N 15/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2412219
The invention features transgenically produced PDGF, e.g., transgenically produced PDGF which is expressed in the milk of a transgenic mammal, and is present in the milk in active form, e.g., as a dimer. The invention also features methods of producing transgenic PDGF, transgenic animals capable of expressing PDGF, and nucleic acid sequences encoding PDGF, e.g., nucleic acid sequences encoding PDGF, under the control of a mammary gland specific promoter.
L'invention porte sur du facteur de croissance d'origine plaquettaire (PDGF) à caractère transgénique, par exemple exprimé dans le lait de mammifères transgéniques et y étant présent sous forme active par exemple comme dimère. L'invention porte également sur des procédés d'obtention de PDGF transgénique, sur des animaux transgéniques susceptibles d'exprimer le PDGF, sur des séquences d'acides nucléique codant pour le PDGF, et sur des séquences d'acides nucléique codant pour le PDGF, par exemple sous l'action d'un promoteur spécifique de glande mammaire.
Echelard Yann
Eichner Wolfram
Meade Harry
Sommermeyer Klaus
Genzyme Transgenics Corp.
Gtc Biotherapeutics Inc.
Smart & Biggar
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