A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/60 (2006.01) A61F 2/10 (2006.01) A61L 15/32 (2006.01) A61L 27/24 (2006.01) A61L 27/38 (2006.01) C12N 5/00 (2006.01)
Patent
CA 2579551
The present invention provides a method for producing an improved biomaterial comprising treating a collagen biomaterial with a transglutaminase under conditions which permit the formation of cross-links within the collagen. Preferably, the transglutaminase is a tissue transglutaminase, a plasma transglutaminase or a microbial transglutaminase. In a preferred embodiment, the collagen biomaterial further comprises a cell adhesion factor, such as fibronectin. The invention further provides biomaterials obtainable by the methods of the invention, and medical implants and wound dressings comprising the same.
L'invention concerne un procédé de production d'un matériau biologique amélioré consistant à traiter un matériau biologique de collagène avec de la transglutaminase dans des conditions permettant la formation réticulaire dans le collagène. De préférence, la transglutaminase consiste en une transglutaminase tissulaire, plasmique ou microbienne. Dans un mode de réalisation préféré, le matériau biologique de collagène comprend, en outre, un facteur d'adhésion de cellule, notamment de la fibronectine. L'invention concerne enfin des matériaux biologiques pouvant être obtenus au moyen des procédés de l'invention, ainsi que des implants médicaux et des pansements contenant ces matériaux biologiques.
Chau David
Collighan Russell
Griffin Martin
Verderio Edwards Elisabetta
Aston University
Borden Ladner Gervais Llp
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