Transglutaminase mediated conjugation of growth hormone

Details Transglutaminase mediated conjugation of growth hormone Transglutaminase mediated conjugation of growth hormone

C - Chemistry, Metallurgy

07

K

C07K 17/08 (2006.01) A61K 47/48 (2006.01) C07K 14/61 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2612794

A method for PEGylating growth hormone, said method comprising reacting growth hormone with an amine comprising nucleophile which further comprises a first functional group in the presence og TGase to form a transaminated growth hormone, followed by a reaction of said transaminated growth hormone with a PEG which has been functionalised with a second functional group, wherein said first and second functional groups are selected so that they react to form a covalent bond.

L'invention concerne un procédé de PEGylation d'une hormone de croissance. Ce procédé consiste à faire réagir une hormone de croissance avec une amine comprenant un nucléophile qui renferme en outre un premier groupe fonctionnel en présence d'une TGase en vue de la formation d'une hormone de croissance transaminée, puis à faire réagir cette hormone de croissance transaminée avec un PEG fonctionnalisé avec un second groupe fonctionnel, lesdits premier et second groupes fonctionnels étant sélectionnés de façon que leur réaction forme une liaison covalente.

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