Transglutaminase mediated conjugation of peptides

Details Transglutaminase mediated conjugation of peptides Transglutaminase mediated conjugation of peptides

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/27 (2006.01) C07K 14/61 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2552043

Methods for conjugating peptides are provided comprising i) reacting a peptide with a first compound comprising a functional group in the presence of a transglutaminase capa-ble of incorporating said compound into the peptide to form a transaminated peptide, and ii) reacting said transaminiated peptide with e.g. a functionalised polymer capable of reacting with the functional group incorporated in the peptide in the enzymatic reaction.

La présente invention se rapporte à des procédés permettant de conjuguer des peptides, qui consistent : i) à faire réagir un peptide avec un premier composé possédant un groupe fonctionnel en présence d'une transglutaminase pouvant incorporer ledit composé dans le peptide, afin de former un peptide transaminé ; et ii) à faire réagir ledit peptide transaminé avec, par exemple, un polymère fonctionnalisé pouvant réagir avec le groupe fonctionnel incorporé dans le peptide lors de la réaction enzymatique.

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