Transition metal complexes of a bis[thiohydrazide amide]...

Details Transition metal complexes of a bis[thiohydrazide amide]... Transition metal complexes of a bis[thiohydrazide amide]...

C - Chemistry, Metallurgy

07

C

C07C 327/56 (2006.01) A61K 31/166 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2740925

The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.

La présente invention concerne un composé comprenant un bis[amide de thiohydrazide] ou une forme déprotonée de celui-ci, complexé à un cation métallique de transition, le bis[amide de thiohydrazide] étant représenté par la formule développée (I) : ou un promédicament, isomère, ester, sel, hydrate, solvate, forme polymorphe ou déprotonée de celui-ci. La présente invention concerne également une composition pharmaceutique comprenant un composé de linvention et un procédé pour son utilisation.

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