Transition state structure of human 5'-methylthioadenosine...

G - Physics – 06 – F

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G06F 19/12 (2011.01) A61K 45/00 (2006.01) C07D 471/04 (2006.01) C07D 473/34 (2006.01) C12N 9/10 (2006.01) C12N 9/99 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2663562

Provided are methods of designing a putative inhibitor of a human 5'- methylthioadenosine phosphorylase (MTAP). Also provided are methods of inhibiting a human MTAP.

L'invention concerne des procédés permettant de concevoir un inhibiteur putatif d'une 5'-méthylthioadénosine phosphorylase (MTAP) humaine. Des procédés d'inhibition de MTAP humaine sont également fournis.

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