Translation enhancer-element dependent vector systems

Details Translation enhancer-element dependent vector systems Translation enhancer-element dependent vector systems

C - Chemistry, Metallurgy

12

N

C12N 15/79 (2006.01) C12N 15/00 (2006.01) C12N 15/57 (2006.01) C12N 15/63 (2006.01) C12N 15/67 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2620420

A translation enhancer-driven positive feedback vector system is disclosed which is designed to facilitate identification of a Translational Enhancer Element (TEE) and to provide a means for overexpression of gene products. The system exploits both transcriptional and translational approaches to control the expression levels of genes and/or gene products. Methods are also disclosed for screening libraries of random nucleotide sequences to identify translational elements and for overproduction of proteins, which have uses in both research and industrial environments.

L'invention concerne un système de vecteur de rétroaction positive régi par activateurs traductionnels conçu pour faciliter l'identification d'un élément d'activation traductionnelle (TEE) et permettant d'obtenir un moyen pour la surexpression de produits génétiques. Ce système fait appel à des approches transcriptionnelle et traductionnelle pour réguler les niveaux d'expression de gènes et/ou de produits génétiques. L'invention concerne également des méthodes destinées à cribler des bibliothèques de séquences nucléotidiques aléatoires en vue de l'identification d'éléments traductionnels et de la détermination d'une surproduction de protéines. Ces méthodes trouvent une utilisation dans des environnements de recherche et des environnements industriels.

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