Translation initiation region sequences for the optimal...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/10 (2006.01)

Patent

CA 2695510

The present invention provides methods and compositions for producing heterologous protein with improved yield and/or quality. A library of randomized ribosomal binding site sequences is provided for the identification of a translation initiation region sequence optimal for expression of the heterologous protein. Also provided are novel ribosomal binding site sequences, and vectors and host cells having those sequences. The library of randomized sequences is useful for screening for improved expression of any protein of interest, including therapeutic proteins, hormones, a growth factors, extracellular receptors or ligands, proteases, kinases, blood proteins, chemokines, cytokines, antibodies and the like.

La présente invention concerne des procédés et des compositions destinés à produire des protéines hétérologues avec un rendement et/ou une qualité améliorés. Une banque de séquences randomisées de sites de liaison des ribosomes est fournie pour l'identification d'une séquence de région d'initiation de la transcription optimale pour l'expression de la protéine hétérologue. De nouvelles séquences de sites de liaison des ribosomes sont également fournies, ainsi que des vecteurs et des cellules hôtes renfermant ces séquences. La banque de séquences randomisées est utile pour un criblage à la recherche d'une expression améliorée de toute protéine d'intérêt, y compris des protéines thérapeutiques, des hormones, des facteurs de croissance, des récepteurs extracellulaires ou des ligands, des protéases, des kinases, des protéines sanguines, des chimiokines, des cytokines, des anticorps et analogues.

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