C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) C07K 14/435 (2006.01) C12Q 1/37 (2006.01) G01N 33/542 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2483144
The present invention relates to various uses of complementing proteins protein fragments to discover chemical compounds or drugs interfering with protein translocation/ redistribution and/or protein interactions. The invention takes advantage of the fact that many interacting proteins reside in separate and distinct locations prior to the activation of the signaling pathways in which they play their part. The invention also takes advantage of interaction domains (FRBP, FKBP12) that can be induced to interact. Specifically disclosed are GFP (EGFP, F64L mutated EYFP) complementation.
La présente invention concerne diverses utilisations de protéines de complémentation, de fragments de protéines de manière à découvrir des composés chimiques ou des médicaments interférant avec la translocation/ la redistribution de protéines et/ou des interactions entre protéines. La méthode de cette invention tire profit du fait que plusieurs protéines à interaction se trouvent à des emplacements distincts et séparés, avant l'activation des voies de signalisation, dans lesquelles elles remplissent leur rôle, ainsi que du fait que des domaines d'interaction (FRBP, FKBP12) peuvent être induits pour interagir. Ladite invention a notamment trait à la complémentation (EGFP, EYFP muté en F64L).
Dahl Soren Weis
Hagel Grith
Nielsen Soren Jensby
Praestegaard Morten
Terry Bernard Robert
Bioimage A/s
Fisher Bioimage Aps
Sim & Mcburney
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