Transmetalations from zirconium to copper intermediates

Details Transmetalations from zirconium to copper intermediates Transmetalations from zirconium to copper intermediates

C - Chemistry, Metallurgy

07

F

C07F 1/08 (2006.01) C07C 405/00 (2006.01)

Patent

CA 2073342

Higher order cuprate complexes are prepared by means of a transmetalation from a corresponding zirconate intermediate. This process is particularly valuable with respect to the preparation of vinylic side chains such as are present in prostaglandins, as it is possible in accordance with the present invention to proceed directly from the acetylenic precursors via the reactive cuprates to the desired final products in a one-pot operation without isolation of intermediates and in high yields. Sequential additions to zirconium intermediates of components which together comprise the cuprate involved in transmetalation with the zirconium inter- mediate are disclosed as alternative procedures.

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