Transmissible spongiform encephalopathy test reagents and...

Details Transmissible spongiform encephalopathy test reagents and... Transmissible spongiform encephalopathy test reagents and...

G - Physics

01

N

G01N 33/68 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2558365

The invention provides improved methods and compositions for selectively binding and/or detecting an aggregating abnormal form of a (prion) protein in the presence of non-aggregating normal form of the (prion) protein, using a polyionic material having a binding avidity for the abnormal aggregating form of the (prion) protein, a switterionic agent (a SWITTERGENT ~ or an EMPIGEN ~ e.g.), and a discrimineting agent (such as laurylsarcosine).

L'invention porte sur des méthodes et compositions améliorées de fixation sélective et/ou de détection de la forme agrégeante anormale d'une protéine en présence de la forme non agrégeante normale de la protéine.

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